0102030405
(R)-1-Boc-3-Aminopiperidine | C10H20N2O2 | CAS 188111-79-7
Property
Alpha: 28.5 º (c=1, DMF)
Boiling point: 277.3±33.0 °C
Density: 1.041±0.06 g/cm3
Refractive index: 1.4730
Storage temp.: Keep in dark place, Inert atmosphere, 2-8°C
Solubility: Chloroform (Slightly), DMF (Slightly), DMSO (Slightly)
Pka: 10.35±0.20
Form: Liquid
Color: Colorless to pale yellow
Optical activity: [α]/D -28.5±2°, c = 1 in DMF
Water Solubility: Immiscible with water.
Application
1. (R)-(-)-3-Amino-1-Boc-piperidine(tert-Butyl (R)-3-Aminopiperidine-1-carboxylate), is an heterocyclic building block used for the synthesis of more complex pharmaceutical compounds. It is also found to act as a γ-secretase modulators, and a potent structure for lowering Ab42 production in both in vitro and in vivo.
2. (R)-3-Amino-1-Boc-piperidine can be used to prepare a benzoxazepine derivative named (R)-7-(3,5-dimethoxyphenyl)-N-(piperidin-3-yl)-4-propionyl-2,3,4,5-tetrahydro-1,4-benzoxazepine-9-carboxamide, a potent CBP/P300 bromodomain inhibitor.
Package And Storage
Package:
25kg/carton drum or as your requirements.
Remark: Chemical composition and size can be optimized by the customers' requirements
Storage:
Separated from ammonium nitrate and potassium chlorate. Dry.Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.
Safety Protection
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.